How can the Department of War develop and implement a comprehensive cyber defense strategy for military and commercial space systems by integrating Cyber-Physical System (CPS) concepts? To effectively identify, characterize, defend against, and respond to cyber-threats and attacks across these critical space-based assets and broader AFIN enclaves, how can this strategy leverage advances in machine learning, artificial intelligence, and cloud computing to create proactive defense capabilities? Furthermore, how can the military achieve holistic cyber situational awareness and apply a standardized cyber risk calculation methodology to reduce vulnerabilities, ultimately gaining strategic, operational, and tactical advantages over peer and near-peer competitors in future conflicts?